Metallo-Liposomes Derived from the [Ru(bpy)3]2+ Complex as Nanocarriers of Therapeutic Agents

The obtaining of nanocarriers gene material and small drugs is still an interesting research line. Side-effects produced by the toxicity several pharmaceutics, high concentrations needed to get therapeutic effects, or their excessive use patients have motivated search for new nanostructures. For these reasons, cationic metallo-liposomes composed phosphatidylcholine (PC), cholesterol (CHO) RuC1C19 (a surfactant derived from metallic complex [Ru(bpy)3]2+) were prepared characterized using diverse techniques (zeta potential, dynamic light scattering electronic transmission microscopy –TEM-). Unimodal bimodal populations spherical aggregates with sizes obtained depending on composition liposomes. presence favored formation aggregates. ct-DNA was condensed in liposomes investigated. In-vitro assays demonstrated ability nanoaggregates internalize into different cell lines. A positive transfection human bone osteosarcoma epithelial cells (U2OS) also observed. used as sensor quantify binding DNA Doxorubicin encapsulated metallo-liposomes, demonstrating be drugs. relationship between then encapsulation percentage antibiotic has been established.